Gene-level kernel and burden association tests of genetic variants with a trait of interest, allowing for related individuals, including twins.
Daniel J. Schaid and Jason P. Sinnwell Small contribution by A. Visconti
Schaid DJ, McDonnell SK., Sinnwell JP, Thibodeau SN. (2013) Multiple Genetic Variant Association Testing by Collapsing and Kernel Methods With Pedigree or Population Structured Data Genet Epidemiol, 37(5):409-18